Scientists discover promising off-switch for inflammation

Scientists have discovered a new metabolic process in the body that can switch off inflammation. They have discovered that 'itaconate' -- a molecule derived from glucose -- acts as a powerful off-switch for macrophages, which are the cells in the immune system that lie at the heart of many inflammatory diseases including arthritis, inflammatory bowel disease and heart disease. The scientists, working in the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute at Tr